is an international not-for-profit and independent organization, dedicated to making up-to-date, accurate information about the effects of healthcare readily available worldwide.
It produces and disseminates systematic reviews of healthcare interventions and promotes the search for evidence in the form of clinical trials and other studies of interventions.
It is important that users can distinguish high quality reviews.
Many instruments have been designed to evaluate different aspects of reviews, but there are few comprehensive critical appraisal instruments.
Systematic review protocols on PROSPERO can include any type of any study design.